Mesoporous silica nanoparticles (MSNs) have seen a fast development as drug delivery carriers thanks to their tunable porosity and high loading capacity. The employ of MSNs in biomedical applications requires a good understanding of their degradation behavior both to control drug release and to assess possible toxicity issues on human health. In this work, we study mesoporous silica degradation in biologically relevant conditions through in situ ellipsometry on model mesoporous nanoparticle or continuous thin films, in buffer solution and in media containing proteins.
Following in Situ the Degradation of Mesoporous Silica in Biorelevant Conditions: At Last, a Good Comprehension of the Structure Influence, Journal of the American Chemical Society 2020
As the world recovers from the lockdown imposed by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, returning to shared indoor spaces is considered a formidable risk. It is now clear that transmission of SARS-CoV-2 is driven by respiratory microdroplets expelled by infected persons, which can become suspended in the air. Several layering technologies are being explored to mitigate indoor transmission in the hopes of re-opening business, schools and transportation systems. Here we coupled the water adsorptive and photocatalytic capacity of novel Metal Organic Frameworks (MOFs) to demonstrate the capture and inactivation of SARS-CoV-2. Discussion is given on the methods of analysis and the differences between the photocatalytic activity of several MOFs, and the difference between MOF induced photocatalysis and ultra violet photolysis of SARS-CoV-2. Our results are intended to provide support to industry looking for alternative methods secure indoor spaces.
Membrane nanotubes are continuously assembled and disassembled by the cell to generate and dispatch transport vesicles, for instance, in endocytosis. While these processes crucially involve the ill-understood local mechanics of the nanotube, existing micromanipulation assays only give access to its global mechanical properties. Here we develop a new platform to study this local mechanics using atomic force microscopy (AFM). On a single coverslip we quickly generate millions of substrate-bound nanotubes, out of which dozens can be imaged by AFM in a single experiment.
Mapping and Modeling the Nanomechanics of Bare and Protein-Coated Lipid Nanotubes, Physical Review X 2020
Efforts to sequence single protein molecules in nanoporeshave been hampered by the lack of techniques with sufficient sensitivity to discern the subtle molecular differences among all twenty amino acids. Here we report ionic current detection of all twenty proteinogenic amino acids in an aerolysin nanopore with the help of a short polycationic carrier. Application of molecular dynamics simulations revealed that the aerolysin nanopore has a built-in single-molecule trap that fully confines a polycationic carrier-bound amino acid inside the sensing region of the aerolysin.
Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore, Nature Biotechnology 2019
In the present work, mesoporous TiO2 with a photonic structure was elaborated using cellulose nanocrystals (CNCs) as a biotemplate by two-step hard template methods.
This strategy enables to replicate the chiral nematic (CN) structure of the photonic films (biotemplate) in TiO2 films.
A series of iridescent CNCs films with different weight ratios of silica/CNCs composite photonic films were prepared via evaporation induced self-assembly (EISA) method.
Improving the photogeneration and the lifetime of charge carriers associated with light harvesting is among the main challenges facing materials for photocatalysis. We report here the synthesis of mesoporous TiO2 containing a replica of a chiral nematic structure (CNS) as a photocatalyst with improved light harvesting and photogenerated charge carriers under UV illumination. The CNS of cellulose nanocrystal photonic films, obtained by an evaporation-induced self-assembly method, were successfully transferred into an inorganic TiO2 film by sol–gel mineralization of the biotemplate.