Publications

Following in Situ the Degradation of Mesoporous Silica in Biorelevant Conditions: At Last, a Good Comprehension of the Structure Influence

Publié le 22/10/2020
n°n°10.1021/acsami.9b19956
Elisa Bindini, Zeinab Chehadi, Marco Faustini, Pierre-Antoine Albouy, David Grosso, Andrea Cattoni, Corinne Chanéac, Omar Azzaroni, Clément Sanchez, and Cédric Boissière
Health, Welfare, Biotechnologies and Industry

Mesoporous silica nanoparticles (MSNs) have seen a fast development as drug delivery carriers thanks to their tunable porosity and high loading capacity. The employ of MSNs in biomedical applications requires a good understanding of their degradation behavior both to control drug release and to assess possible toxicity issues on human health. In this work, we study mesoporous silica degradation in biologically relevant conditions through in situ ellipsometry on model mesoporous nanoparticle or continuous thin films, in buffer solution and in media containing proteins.

 

Following in Situ the Degradation of Mesoporous Silica in Biorelevant Conditions: At Last, a Good Comprehension of the Structure Influence, Journal of the American Chemical Society 2020

SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis

Publié le 07/10/2020
n°N° doi: https://doi.org/10.1101/2020.10.01.20204214
Jason Mathew Ornstein, View ORCID ProfileRay Ozdemir, Anne Boehme, Christian Serre, Farid Nouar, Joshua Santarpia, Vicki L. Herrera, Daniel N. Ackerman
Health, Welfare, Biotechnologies and Industry

As the world recovers from the lockdown imposed by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, returning to shared indoor spaces is considered a formidable risk. It is now clear that transmission of SARS-CoV-2 is driven by respiratory microdroplets expelled by infected persons, which can become suspended in the air. Several layering technologies are being explored to mitigate indoor transmission in the hopes of re-opening business, schools and transportation systems. Here we coupled the water adsorptive and photocatalytic capacity of novel Metal Organic Frameworks (MOFs) to demonstrate the capture and inactivation of SARS-CoV-2. Discussion is given on the methods of analysis and the differences between the photocatalytic activity of several MOFs, and the difference between MOF induced photocatalysis and ultra violet photolysis of SARS-CoV-2. Our results are intended to provide support to industry looking for alternative methods secure indoor spaces.

 

SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis

Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore

Publié le 19/12/2019
n°10.1038/s41587-019-0345-2
Hadjer Ouldali, Kumar Sarthak, Tobias Ensslen, Fabien Piguet, Philippe Manivet, Juan Pelta, Jan C. Behrends, Aleksei Aksimentiev, Abdelghani Oukhaled
Health, Welfare, Biotechnologies and Industry

Efforts to sequence single protein molecules in nanoporeshave been hampered by the lack of techniques with sufficient sensitivity to discern the subtle molecular differences among all twenty amino acids. Here we report ionic current detection of all twenty proteinogenic amino acids in an aerolysin nanopore with the help of a short polycationic carrier. Application of molecular dynamics simulations revealed that the aerolysin nanopore has a built-in single-molecule trap that fully confines a polycationic carrier-bound amino acid inside the sensing region of the aerolysin.

 

Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore, Nature Biotechnology 2019

Photonic titanium dioxide film obtained from hard template with chiral nematic structure for environmental application

Publié le 02/09/2019
n°10.1016/j.cattod.2019.01.030
Chunyu Li, Erwan Paineau, François Brisset, Sylvain Franger, Christophe Colbeau-Justin, Mohamed N.Ghazzal
Environmental sciences and Safety

In the present work, mesoporous TiO2 with a photonic structure was elaborated using cellulose nanocrystals (CNCs) as a biotemplate by two-step hard template methods.

This strategy enables to replicate the chiral nematic (CN) structure of the photonic films (biotemplate) in TiO2 films.

A series of iridescent CNCs films with different weight ratios of silica/CNCs composite photonic films were prepared via evaporation induced self-assembly (EISA) method.

 

Photonic titanium dioxide film obtained from hard template with chiral nematic structure for environmental application, Catalysis Today 2019

Enhanced photogenerated charge carriers and photocatalytic activity of biotemplated mesoporous TiO2 films with a chiral nematic structure

Publié le 06/06/2019
n°10.1021/acs.chemmater.9b01465
Getaneh Diress Gesesse, Chunyu Li, Erwan Paineau, Youssef Habibi, Hynd Remita, Christophe Colbeau-Justin, Mohamed Nawfal-Ghazzal
Renewable energies

Improving the photogeneration and the lifetime of charge carriers associated with light harvesting is among the main challenges facing materials for photocatalysis. We report here the synthesis of mesoporous TiO2 containing a replica of a chiral nematic structure (CNS) as a photocatalyst with improved light harvesting and photogenerated charge carriers under UV illumination. The CNS of cellulose nanocrystal photonic films, obtained by an evaporation-induced self-assembly method, were successfully transferred into an inorganic TiO2 film by sol–gel mineralization of the biotemplate.

 

Enhanced photogenerated charge carriers and photocatalytic activity of biotemplated mesoporous TiO2 films with a chiral nematic structure, American Chemical Society

Aerolysin, a powerful protein sensor for fundamentalstudies and development of upcoming applications

Publié le 23/03/2019
n°10.1021/acssensors.8b01636
Benjamin Cressiot, Hadjer Ouldali, Manuela Pastoriza-Gallego, F. Gisou van der Goo, Laurent Bacri, Juan Pelta
Environmental sciences and Safety

Nanopore electrical approach is a breakthrough in single molecular level detection of particles as small  as  ions,  and  complex  as  biomolecules.

This  technique  can  be  used  for  molecule  analysis, and characterization as well as for the understanding of confined medium dynamics in chemical or biological reactions.

Altogether, the information obtained from these kinds of experiments will allow to address challenges in a variety of biological fields. The sensing, design and manufacture ofnanopores is crucial to obtain these objectives.

 

Aerolysin, a powerful protein sensor for fundamentalstudies and development of upcoming applications, HAL Archives 2019